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Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 8-12 doi: 10.1007/s11684-009-0017-6

Abstract: Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells.is suggested to be involved in neurofibrillary tangle (NFT) formation, disturbed amyloid precursor proteinBased on our research and other previous findings, decreased PP2Ac level, decreased PP2A holoenzyme composition, increased level of PP2A inhibitors, increased PP2Ac Leu309 demethylation and Tyr307 phosphorylationFurther studies are required to disclose the role of PP2A in Alzheimer’s disease.

Keywords： protein phosphatase 2A     Alzheimer’s disease     holoenzyme composition     protein phosphatase 2A inhibitors     Leu309    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: this study is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation, proteinphosphatase 2A (PP2A) activity, and on tau phosphorylation.of Src protein, and the phosphorylation levels of PP2A Y307 and tau at different sites, as well as PP2ATwelve hours after siRNA transfection, the protein level of Src was dramatically decreased, with decreasedHowever, the total PP2A protein level was also decreased, together with a decreased PP2A activity.

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11705-014-1454-6

Abstract: The aggregation of amyloid -protein (A ) is tightly linked to the pathogenesis of Alzheimer’s diseasePrevious studies have found that three peptide inhibitors (i.e., KLVFF, VVIA, and LPFFD) can inhibitHowever, atomic details of binding modes and binding affinities between these peptide inhibitors andAll inhibitors exhibit varied binding affinity to A , in which KLVFF has the highest binding affinityMM/PBSA analysis further revealed that different peptide inhibitors have different modes of interaction

Keywords： Alzheimer’s disease     amyloid β-protein     peptide inhibitors     protein-protein interaction     molecular    

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Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 46-53 doi: 10.1007/s11684-010-0010-0

Abstract: Mitogen-activated protein kinase (MAPK) signaling pathway, one of the most important signaling pathwaysSo far, inhibitors specifically against each subfamilies of MAP kinase have been developed, while moreMost of the kinase inhibitors exert their functions in an ATP-competitive way or a non-ATP-competitiveFurther studies on the effective mechanism of the MAPK inhibitors and their therapeutic roles in thetreatment of diseases are helpful for the illumination of MAP kinase function, the development of novel inhibitors

Keywords： mitogen-activated protein kinase     drug target     inhibitor     signal transduction     disease    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract: In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Complete Genome Sequence of Shigella flexneri 2a 301 Strain and Analysis of “Shigella-islands”

Liu Hong,Yang Fan,Zhang Xiaobing,Zhang Jiyu,Yang Guowei,Dong Jie,Xue Ying,Hou Yunde,Yuan Zhenghong,Wen Yumei,Xu Jianguo,Cheng Hongsong,Ma Dalong,Wang Yu,Yang Jian,Shen Yan,Qiang Boqin,Wu Hongtao,Lü Weichuan,Jin Qi

Strategic Study of CAE 2002, Volume 4, Issue 10,   Pages 40-47

Abstract:

Shigella flexneri serotype 2a are the most prevalent species and serotype that cause .bacillary dysenteryThis paper presents the complete genome sequence of a Shigella flexneri 2a strain which isolated fromthe primary analysis of “ Shigella-genomic islands (SIs)，” that means Shigella flexneri 2athem, the authors identified 7 putative Sis with typical structure of pathogenicity islands (PAI) and 2lipopolysaccharide (LPS) have implications in virulence, in addition to the previously identified PAIs, SHE and SHI-2.

Keywords： Shigella flexneri 2a 301 strain     genome sequence     genomic island     pathogenicity island    

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Dual faces of SH2-containing protein-tyrosine phosphatase

Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 275-279 doi: 10.1007/s11684-012-0216-4

Abstract:

PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses toHowever, most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesisThis review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in

Keywords： PTPN11/Shp2     leukemia     hepatocellular carcinoma     mutation    

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Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 390-395 doi: 10.1007/s11684-009-0087-5

Abstract: We constructed a eukaryotic expression plasmid encoding Epstein-Barr virus latent membrane protein 2(EBV, LMP2) and evaluated its effects on humoral immunity.The serum antibody against LMP2 was detected with enzyme-linked immunosorbent assay (ELISA).The serum titer of IgG antibody against LMP2 epitope in the mice immunized with the DNA vaccine encodingLMP2 was up to 1∶4000.

Keywords： Epstein-Barr virus     latent membrane protein 2     nasopharyngeal carcinoma     humoral immunity    

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Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 166-170 doi: 10.1007/s11684-008-0030-1

Abstract: This study aims to demonstrate that blocking the receptor-interacting protein2 (Rip2) expression canconcentration was assayed with ELISA and high-mobility group box 1 protein (HMGB1) level with semi-quantitativeRip2 siRNA plasmid could block the mRNA and protein expression of Rip2 and promote cell proliferationBlocking Rip2 could attenuate LPS-induced TNF-? and HMGB1 production.The results demonstrate that Rip2 siRNA plasmid can block the expression of Rip2, decrease the production
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Measurement of bone alkaline phosphatase and relative study with osteosarcoma

YANG Zhiping, LI Jianmin, LI Xin, HUO Yanqing, SUN Guangzhi

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 54-57 doi: 10.1007/s11684-007-0011-9

Abstract: The objective of this paper is to explore the value of bone alkaline phosphatase (BALP) for diagnosingAlkaline phosphatase (ALP) in blood serum was checked with auto biochemistry equipment.
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Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 410-422 doi: 10.1007/s11684-017-0527-6

Abstract: protein causes lethal hyperfibrinolysis in acute promyelocytic leukemia (APL), but the mechanism isacid receptor a (PML/RARα) fusion protein, this work was performed to determine the transcriptionZinc-induced U937/PR9 cells expressed PML/RARα fusion protein, and resultant increases in ANXA2The transactivation of ANXA2 promoter by PML/RARα fusion protein was 3.29±0.13 fold higherThus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate

Keywords： annexin A2-S100A10 heterotetramer     PML/RARα fusion protein     plasmin     cell invasion     acute promyelocytic leukemia    

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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2

Keywords： palmitate     characteristic     study     plasma     resistance    

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Synthesis of mono and bis-4-methylpiperidiniummethyl-urea as corrosion inhibitors for steel in acidic

Abbas TEIMOURI, Nasrin SOLTANI, Alireza Najafi CHERMAHINI

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 1,   Pages 43-50 doi: 10.1007/s11705-010-0532-7

Abstract: Mono and bis-4-methylpiperidiniummethyl urea were synthesized, characterized and used as new corrosion inhibitorsPotentiodynamic polarization measurements showed that two inhibitors are mixed type.This reveals that inhibitive actions of inhibitors were mainly due to adsorption on mild steel surface

Keywords： corrosion inhibitors     mild steel     acidic medium     theoretical studies     DFT    

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Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 24-31 doi: 10.1007/s11684-019-0679-7

Abstract: Immune checkpoint inhibitors are a promising strategy in the treatment of cancer, especially advancedHowever, not all patients are responsive to immune checkpoint inhibitors.of data, which allow researchers to explore responsive or resistant biomarkers of immune checkpoint inhibitors

Keywords： immune checkpoint blockade     sensitivity     resistance     data mining    

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Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 307-321 doi: 10.1007/s11684-022-0927-0

Abstract: The discovery of immune checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has played an importantwidely applied in clinical treatment, and they are inevitably used in combination with immune checkpoint inhibitorsClinical practice has revealed that antibiotics can weaken the therapeutic response to immune checkpoint inhibitorsStudies have shown that the gut microbiota is essential for the interaction between immune checkpoint inhibitorsThis review focuses on the interactions between immune checkpoint inhibitors and antibiotics, with an

Keywords： tumor immunotherapy     immune checkpoint inhibitor     antibiotics     gut microbiota     drug–drug interaction    

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Title Author Date Type Operation

Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article

Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Journal Article

Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article

Complete Genome Sequence of Shigella flexneri 2a 301 Strain and Analysis of “Shigella-islands”

Liu Hong,Yang Fan,Zhang Xiaobing,Zhang Jiyu,Yang Guowei,Dong Jie,Xue Ying,Hou Yunde,Yuan Zhenghong,Wen Yumei,Xu Jianguo,Cheng Hongsong,Ma Dalong,Wang Yu,Yang Jian,Shen Yan,Qiang Boqin,Wu Hongtao,Lü Weichuan,Jin Qi

Journal Article

Dual faces of SH2-containing protein-tyrosine phosphatase

Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng

Journal Article

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Journal Article

Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Journal Article

Measurement of bone alkaline phosphatase and relative study with osteosarcoma

YANG Zhiping, LI Jianmin, LI Xin, HUO Yanqing, SUN Guangzhi

Journal Article

Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Synthesis of mono and bis-4-methylpiperidiniummethyl-urea as corrosion inhibitors for steel in acidic

Abbas TEIMOURI, Nasrin SOLTANI, Alireza Najafi CHERMAHINI

Journal Article

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Journal Article

Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Journal Article